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Protein analysis may reveal new cancer treatment targets

Researchers have used lab technology called mass spectrometry to study the proteins expressed by human cancer cells. The advance, which is described in a new Molecular Oncology article, allows for the quantitation of thousands of tumour proteins over the course of several hours.

 

Enhancing the potency and specificity of engineered T cells for cancer treatment

The adoptive transfer of chimeric antigen receptor (CAR)-modified T cells has produced tumor responses even in patients with refractory diseases. However, the paucity of antigens that are tumor selective has resulted, on occasion, in "on-target, off-tumor" toxicities.

A serious new hurdle for CRISPR: Edited cells might cause cancer, find two studies

Editing cells’ genomes with CRISPR-Cas9 might increase the risk that the altered cells, intended to treat disease, will trigger cancer, two studies published on Monday warn — a potential game-changer for the companies developing CRISPR-based therapies.

 

June is National Cancer Survivor month

It is a time to celebrate those who have survived, to inspire those who are recently diagnosed and a source of support for all of their families. 

Immunostimulators and Immunomodulators in Cancer Treatment

The immune system uses an extremely complex regulatory system to achieve the goal of effectively eradicating pathogens without causing excessive host tissue damage. A successfully coordinated immune response is dependent on secreted chemical signals (cytokines), protein–protein interactions between adjacent cells, and the activity of various enzymes that alter the microenvironment. 

New screening guidelines for colon cancer

The American Cancer Society has released new age guidelines for adults of average risk to being colon cancer screening. The new recommended age is now 45 for both men and women.

Obesity Drives Liver Cancer in Developed Nations

Liver cancer cases in several developed countries have doubled in the past 25 years, due to the continuing obesity epidemic and a spike in hepatitis infections, new research suggests.

Treatment of Screen-Detected Breast Cancer

Women diagnosed with breast cancer by breast screening have a better survival than women with symptomatic breast cancer, even after adjustment for age, nodal status, and tumor size. Breast screening identifies many noninvasive and invasive breast cancers with a low rate of subsequent recurrence or death. Between 11% and 19% of screen-detected breast cancers are overdiagnosed, that is, that had they not been screened the patient would not have known that they had breast cancer, nor required treatment within their lifetime.

New cancer treatment grabs hold of malignant cells and calls in the troops

Cancer is one of the topmost killers worldwide. The complexity and wide variety of types makes it hard to find one useful therapy to neutralize it, without harming healthy tissue. Now, researchers at The Scripps Research Institute in Florida think they’ve developed one. Their report was published in The Proceedings of the National Academy of Sciences (PNAS). It all surrounds immunotherapy.

Detecting Lung Cancer From Simple Blood Draw

Two years ago, this was a "pipe dream" but "today, we actually have data to show this is really feasible to find early-stage cancer in the blood," said lead investigator Geoffrey R. Oxnard, MD, associate professor of medicine at Dana-Farber Cancer Institute and Harvard Medical School in Boston, Massachusetts.

 

Chemotherapy before surgery could extend pancreatic cancer patients' lives

Clinical trial finds those given chemoradiotherapy 10 weeks before surgery for deadly disease lived months longer

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