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Risk-based CT screening may reduce deaths from lung cancer

January 3, 2018

Compared to National Lung Screening Trial criteria, targeting screening those at highest risk from lung cancer mortality using a risk prediction tool may improve efficiency in terms of greater reduction in mortality from lung cancer in the short term per person screened. However, such a targeted approach does not offer substantial gains in terms of life-years saved, quality-adjusted life-years (QALYs), and cost-effectiveness. The findings are published in Annals of Internal Medicine.

Most current lung cancers screening guidelines, including those from the U.S. Preventive Services Task Force (USPSTF), use screening criteria based on findings from the National Lung Screening Trial. Therefore, screening is recommended for persons between the ages of 55 and 74 years with a smoking history of at least 30 pack-years and former smokers who had no more than 15 years of smoking abstinence. However, targeting low-dose computed tomography (LDCT) for lung cancer screening to persons at highest risk for lung cancer mortality has been suggested as a way to improve screening efficiency.

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